| Year | Type | Title | Character |
|---|---|---|---|
| 2017+ | Sgt. Stubby: An American Hero | Margaret Conroy | |
| 2018 | Film | Ocean's Eight | TBA |
| 2016+ | Saint Maizie | Maizie, Producer | |
| 2016+ | TV Series | Codes of Conduct | Esther Kaufmann |
| 2016+ | Mini-Series | Love, Nina | Georgia |
| 2016 | Film | The Guns of August | Margot Asquith |
| 2016 | Film | 55 Steps | Eleanor Riise |
| 2016 | Film | Through the Looking Glass | The Red Queen |
| 2015 | Film | Cinderella | Fairy Godmother |
| 2015 | Film | Suffragette | Edith Ellyn |
| 2014 | Film | The Young and Prodigious T.S. Spivet | Dr. Clair |
| 2014 | TV Film | Salting the Battlefield | Margot Tyrrell |
| 2014 | TV Film | Turks & Caicos | Margot Tyrrell |
| 2013 | Film | The Lone Ranger | Red Harrington |
| 2013 | TV Film | Burton & Taylor | Elizabeth Taylor |
| 2012 | Film | Les Misérables | Madame Thénardier |
| 2012 | Film | Great Expectations | Miss Havisham |
| 2012 | Film | Dark Shadows | Dr Julia Hoffman |
| 2012 | Short | A Therapy | Patient |
| 2011 | Film | Harry Potter and the Deathly Hallows: Part II | Bellatrix Lestrange |
| 2011 | Animated | The Gruffalo's Child | Mother Squirrel |
| 2011 | TV Series | Life’s Too Short "Episode 1.3" | Herself |
| 2010 | Film | Harry Potter and the Deathly Hallows: Part I | Bellatrix Lestrange |
| 2010 | Film | The King's Speech | (Queen) Elizabeth Bowes-Lyon |
| 2010 | Film | Alice in Wonderland | The Red Queen |
| 2010 | TV Film | Toast | Joan Potter |
| 2009 | Film | Harry Potter and the Half-Blood Prince | Bellatrix Lestrange |
| 2009 | Film | Terminator: Salvation | Dr. Serena Kogan |
| 2009 | TV Film | Enid | Enid Blyton |
| 2009 | Animated | The Gruffalo | Mother Squirrel |
| 2007 | Film | Sweeney Todd: The Demon Barber of Fleet Street | Mrs. Lovett |
| 2007 | Film | Harry Potter and the Order of the Phoenix | Bellatrix Lestrange |
| 2006 | Film | Sixty Six | Esther Rubens |
| 2005 | Film | Conversations with Other Women | Woman |
| 2005 | Film | Charlie and the Chocolate Factory | Mrs. Bucket |
| 2005 | TV Film | Magnificent 7 | Maggi Jackson |
| 2005 | Animated | Corpse Bride | Emily, Corpse Bride |
| 2005 | Animated | Wallace & Gromit: The Curse of the Were-Rabbit | Lady Tottington |
| 2004 | Mini-Series | Henry VIII | Anne Boleyn |
| 2003 | Film | Big Fish | Jenny / the Witch |
| 2002 | Film | Till Human Voices Wake Us | Ruby |
| 2002 | Film | The Heart of Me | Dinah |
| 2002 | TV Film | Live from Baghdad | Ingrid Formanek |
| 2001 | Film | Novocaine | Susan Ivy |
| 2001 | Film | Planet of the Apes | Ari |
| 2001 | Short | Football | Mum |
| 2000 | Childrens | Carnivale | Milly |
| 1999 | Film | Women Talking Dirty | Cora |
| 1999 | Film | Fight Club | Marla Singer |
| 1999 | Mini-Series | The Nearly Complete and Utter History of Everything | Lily |
| 1998 | Film | The Theory of Flight | Jane Hatchard |
| 1998 | Mini-Series | Merlin | Morgan Le Fay |
| 1998 | Film | The Revengers' Comedies | Karen Knightley |
| 1998 | Unknown | Hysteria | Unknown |
| 1997 | Film | Keep the Aspidistra Flying | Rosemary |
| 1997 | Film | The Wings of the Dove | Kate Croy |
| 1997 | Narrator | The Petticoat Expeditions | Narrator |
| 1996 | Film | Portraits Chinois | Ada |
| 1996 | Film | Twelfth Night: Or What You Will | Olivia |
| 1996 | TV Series | 1914-1918 "Explosion" "Slaughter" | Vera Brittain |
| 1995 | Film | Mighty Aphrodite | Amanda |
| 1995 | Film | Margaret’s Museum | Margaret MacNeil |
| 1995 | TV Film | Jeremy Hardy Gives Good Sex | Multiple |
| 1994 | Film | Mary Shelley’s Frankenstein | Elizabeth Frankenstein |
| 1994 | TV Film | A Dark Adapted Eye | Faith Severn |
| 1994 | TV Series | Absolutely Fabulous "Hospital" | Dream Saffron |
| 1994 | Short | Butter | Dorothy |
| 1994 | Short | The Gallery | Dorinda |
| 1993 | TV Film | Fatal Deception: Mrs. Lee Harvey Oswald | Marina Oswald |
| 1993 | TV Film | Dancing Queen | Pandora / Julie |
| 1993 | TV Series | The Good Sex Guide "Episode 2.1" | Multiple |
| 1993 | Short | A Little Loving | Flora |
| 1992 | Film | Howards End | Helen Schlegel |
| 1992 | Animated | White Bear’s Secret | White Bear |
| 1991 | Film | Where Angels Fear to Tread | Caroline Abbott |
| 1991 | Animated | Brown Bear's Wedding | White Bear |
| 1991 | Childrens | Jackanory "The Way to Sattin Shore: Part 5" "The Way to Sattin Shore: Part 4" "The Way to Sattin Shore: Part 3" "The Way to Sattin Shore: Part 2" "The Way to Sattin Shore: Part 1" | Reader |
| 1990 | Film | Hamlet | Ophelia |
| 1989 | Film | Getting It Right | Lady Minerva Munday |
| 1989 | Film | Francesco | Chiara Offreduccio |
| 1989 | TV Series | Theatre Night "Arms and the Man" | Raina Petkoff |
| 1988 | Film | La Maschera | Iris |
| 1988 | Short | Six Minutes with Ludwig | The Star |
| 1987 | Film | Maurice | Woman at the cricket match (uncredited) |
| 1987 | TV Film | A Hazard of Hearts | Serena Staverley |
| 1987 | TV Series | Screen Two "The Vision" | Jo Marriner |
| 1987 | TV Series | Miami Vice "Theresa" "The Savage" | Dr. Theresa Lyons |
| 1986 | Film | Lady Jane | Lady Jane Grey |
| 1985 | Film | A Room with a View | Lucy Honeychurch |
| 1983 | TV Film | A Pattern of Roses | Netty Bellinger |